
Targacept, Inc.
200 East First Street, Suite 300Winston-Salem, NC 27101-4165 Therapeutic Focus:Central nervous system diseases and disordersTherapeutic Targets: Neuronal nicotinic receptors (NNRs), which are key regulators of the nervous systemProduct Candidates: TC-5214, major depressive disorder; AZD3480 (TC-1734), attention deficit/hyperactivity disorder (ADHD); AZD1446 (TC-6683), Alzheimer's disease; TC-5619, cognitive dysfunction in schizophrenia or one or more other indications characterized by cognitive impairment; and TC-5685, depression/anxiety disorders. |
President & CEO: J. Donald deBethizy, Ph.D.
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Strategic Alliances:
Global collaboration and license agreement with AstraZeneca for TC-5214 for the treatment of major depressive disorder.
Exclusive global license and research collaboration with AstraZeneca AB for the development and commercialization of AZD3480 (TC-1734) to treat ADHD and AZD1446 (TC-6683) to treat Alzheimer's disease and potentially other cognitive disorders.
In addition, as of November 2007, TC-5619 is subject to a future option of AstraZeneca for an exclusive license under the collaboration agreement.
Exclusive global strategic alliance with GlaxoSmithKline focused in five therapeutic areas: smoking cessation, pain, obesity, addiction and Parkinson's disease.
Intellectual Property: PentadTM, a proprietary drug discovery platform; and an extensive patent estate covering compounds that act on NNRs
Product:
Inversine® (mecamylamine HCl), indicated for the treatment of moderately severe to severe essential hypertension and for uncomplicated cases of malignant hypertension
Intellectual Property: PentadTM, a proprietary drug discovery platform; and an extensive patent estate covering compounds that act on NNRs


