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Targacept to Present at Thomas Weisel Partners Healthcare Conference

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Targacept to Present at Thomas Weisel Partners Healthcare Conference

WINSTON-SALEM, N.C.

August 30, 2006

Targacept, Inc. (Nasdaq: TRGT), today announced that J. Donald deBethizy, Ph.D., President and Chief Executive Officer, is scheduled to present at the Thomas Weisel Partners Healthcare Conference being held September 6-8, 2006 at The Four Seasons Hotel in Boston. Dr. deBethizy will present an overview of Targacept and its product development programs on Thursday, September 7 at 3:15 p.m. Eastern Time.

The Targacept presentation will be webcast and accessible from the Investor Relations section of the Company's website, http://www.targacept.com. The webcast will also be available for replay on the Company's website following the conference until October 6. To ensure a timely connection to the webcast, it is recommended that users register at least 15 minutes prior to the scheduled start time.

About Targacept
Targacept is a clinical-stage biopharmaceutical company that discovers and develops NNR-selective therapeutics, a new class of drugs for the treatment of central nervous system diseases and disorders. Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic effects and limit adverse side effects. Targacept has product candidates in development for Alzheimer's disease and cognitive deficits in schizophrenia, pain and depression and multiple preclinical programs. Targacept is located in Winston-Salem, North Carolina.


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