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Targacept to Present at Deutsche Bank 33rd Annual Health Care Conference

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Targacept to Present at Deutsche Bank 33rd Annual Health Care Conference

April 30, 2008

Targacept, Inc. (NASDAQ:TRGT), a clinical-stage biopharmaceutical company developing a new class of drugs known as NNR Therapeutics (TM), today announced that J. Donald deBethizy, Ph.D., President and Chief Executive Officer, is scheduled to present at the Deutsche Bank 33rd Annual Health Care Conference at The InterContinental in Boston, on Wednesday, May 7, 2008 at 8:10 a.m. Eastern Daylight Time.

Dr. deBethizy's presentation will be webcast and accessible from the Investor Relations section of the Company's website, http://www.targacept.com. The webcast will also be available for replay on the Company's website for at least two weeks following the presentation. To ensure a timely connection to the webcast, it is recommended that users register at least 15 minutes prior to the scheduled start time.

About Targacept
Targacept is a clinical-stage biopharmaceutical company that discovers and develops NNR Therapeutics (TM), a new class of drugs for the treatment of central nervous system diseases and disorders. Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic effects and limit adverse side effects. Targacept has product candidates in development for Alzheimer's disease, cognitive dysfunction in schizophrenia, pain and depression, as well as multiple preclinical programs. Targacept also has a cognition-focused collaboration with AstraZeneca and a strategic alliance with GlaxoSmithKline. Targacept's news releases are available on its website at www.targacept.com.

Contacts
Alan Musso, VP and CFO
336-480-2186
alan.musso@targacept.com
or
Linnden Communications
Michelle Linn
508-362-3087
michelle@linndencom.com


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